Abstract
Three patients in whom Class IC sodium channel blockers induced ST segment elevation in leads V1 through V3 are described. The underlying electrophysiologic mechanism, implications for drug-induced proarrhythmia, and the relationship of the finding to the Brugada syndrome type of idiopathic ventricular fibrillation are discussed.
MeSH terms
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Anti-Arrhythmia Agents / pharmacology*
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Arrhythmias, Cardiac / chemically induced*
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Arrhythmias, Cardiac / physiopathology
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Atrial Fibrillation / physiopathology
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Cardiomyopathy, Dilated / physiopathology
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Electrocardiography / drug effects*
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Electrophysiology
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Encainide / pharmacology
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Flecainide / pharmacology
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Humans
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Male
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Middle Aged
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Sodium Channel Blockers
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Ventricular Fibrillation / physiopathology
Substances
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Anti-Arrhythmia Agents
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Sodium Channel Blockers
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Flecainide
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Encainide