Understanding the relationship between genetic variation and biological function on a
genomic scale is expected to provide fundamental new insights into the biology, evolution …

Genome-wide association studies with SNP markers are expected to allow identification of
genes that underlie complex disorders. Hundreds of thousands of SNP markers will be …

In the minisequencing primer extension reaction, a DNA polymerase is used specifically to
extend a primer that anneals immediately adjacent to the nucleotide position to be analyzed …

Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide.
To date, identification of common genetic variants influencing blood pressure has proven …

Genome sequencing projects are discovering millions of genetic variants in humans, and
interpretation of their functional effects is essential for understanding the genetic basis of …

Background Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease in
which the risk of disease is influenced by complex genetic and environmental contributions …

Genome-wide association studies have recently identified at least 15 susceptibility loci for
systemic lupus erythematosus (SLE). To confirm additional risk loci, we selected SNPs from …

We report a high-quality draft sequence of the genome of the horse (Equus caballus). The
genome is relatively repetitive but has little segmental duplication. Chromosomes appear to …

Systemic lupus erythematosus (SLE) is a genetically complex autoimmune disease
characterized by loss of immune tolerance to nuclear and cell surface antigens. Previous …

Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease caused by
both genetic and environmental factors. Genome scans in families with SLE point to multiple …