The members of the Task Force on Sudden Death dedicate this paper to the memory of our
former friend and colleague, Professor Ronald WF Campbell. Ronnie spent his life working …

Objectives: We sought to evaluate the long-term impact of cardiac resynchronization therapy
(CRT) on left ventricular (LV) performance and remodeling using three-dimensional …

When aspirin is administered by mouth in low doses, poor systemic bioavailability may
contribute to its apparent dose-related" selective inhibition" of THROMBOXANE A2 …

Objectives: A randomized trial was done to compare single-chamber atrial (AAI) and dual-
chamber (DDD) pacing in patients with sick sinus syndrome (SSS). Primary end points were …

Background In a previous study of 225 patients with sicksinus syndrome randomised to
either single-chamber atrial pacing (n= 110) or single-chamber ventricular pacing (n= 115) …

Prostacyclin is a potent vasodilator and platelet inhibitor produced by vascular endothelium.
Endogenous production of prostacyclin under physiologic conditions is extremely low, far …

Background—Cardiac resynchronization therapy (CRT) by means of simultaneous
biventricular pacing improves left ventricular systolic performance and synchrony in patients …

We identified the α-cardiac actin gene (ACTC) as a novel disease gene in a pedigree
suffering from familial hypertrophic cardiomyopathy (FHC). Linkage analyses excluded all …

THE APPRECIATION that two oxygenated metabolites of arachidonic acid, prostacyclin
(PGI2) and thromboxane A2 (TxA2), have potent and contrasting effects on vascular tone …

Ubiquitination is a post-translational modification (PTM) that is essential for balancing
numerous physiological processes. To enable delineation of protein ubiquitination at a site …