[HTML][HTML] DNA methylation aging clocks: challenges and recommendations
Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …
From promises to practical strategies in epigenetic epidemiology
J Mill, BT Heijmans - Nature Reviews Genetics, 2013 - nature.com
The epigenome has been heralded as a key'missing piece'of the aetiological puzzle for
complex phenotypes across the biomedical sciences. The standard research approaches …
complex phenotypes across the biomedical sciences. The standard research approaches …
The epigenome: archive of the prenatal environment
World-wide, research initiatives are in progress to establish the role of the epigenome in
human disease. Empirical data are still scarce, but particularly studies investigating how the …
human disease. Empirical data are still scarce, but particularly studies investigating how the …
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression
Trait-associated genetic variants affect complex phenotypes primarily via regulatory
mechanisms on the transcriptome. To investigate the genetics of gene expression, we …
mechanisms on the transcriptome. To investigate the genetics of gene expression, we …
Persistent epigenetic differences associated with prenatal exposure to famine in humans
Extensive epidemiologic studies have suggested that adult disease risk is associated with
adverse environmental conditions early in development. Although the mechanisms behind …
adverse environmental conditions early in development. Although the mechanisms behind …
DNA methylation differences after exposure to prenatal famine are common and timing-and sex-specific
Prenatal famine in humans has been associated with various later-life consequences,
depending on the gestational timing of the insult and the sex of the exposed individual …
depending on the gestational timing of the insult and the sex of the exposed individual …
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity
S Wahl, A Drong, B Lehne, M Loh, WR Scott, S Kunze… - Nature, 2017 - nature.com
Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at
risk of developing type 2 diabetes, cardiovascular disease and related metabolic and …
risk of developing type 2 diabetes, cardiovascular disease and related metabolic and …
Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis
While many disease-associated variants have been identified through genome-wide
association studies, their downstream molecular consequences remain unclear. To identify …
association studies, their downstream molecular consequences remain unclear. To identify …
Disease variants alter transcription factor levels and methylation of their binding sites
Most disease-associated genetic variants are noncoding, making it challenging to design
experiments to understand their functional consequences,. Identification of expression …
experiments to understand their functional consequences,. Identification of expression …
[HTML][HTML] DNA methylation signatures link prenatal famine exposure to growth and metabolism
Periconceptional diet may persistently influence DNA methylation levels with phenotypic
consequences. However, a comprehensive assessment of the characteristics of prenatal …
consequences. However, a comprehensive assessment of the characteristics of prenatal …