Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease
D Pons, FR de Vries, PJ van den Elsen… - European heart …, 2009 - academic.oup.com
Significant progress has been made in the clinical management of a variety of
cardiovascular diseases. Nevertheless, the therapeutic efficacy of the current treatment …
cardiovascular diseases. Nevertheless, the therapeutic efficacy of the current treatment …
[HTML][HTML] Factor VII activating protease polymorphism (G534E) is associated with increased risk for stroke and mortality
Introduction. The FSAP-Marburg I polymorphism (1704G> A), which reduces FSAP activity,
is associated with late complications of carotid stenosis in humans. Therefore, this study …
is associated with late complications of carotid stenosis in humans. Therefore, this study …
Genetic variation in the interleukin‐10 gene promoter and risk of coronary and cerebrovascular events: the PROSPER study
S Trompet, D Pons, AJM de Craen… - Annals of the New …, 2007 - Wiley Online Library
Proinflammatory cytokines, like interleukin‐6 (IL‐6) and tumor necrosis factor‐alpha (TNF‐
α), are implicated in the development of atherosclerosis. The role of anti‐inflammatory …
α), are implicated in the development of atherosclerosis. The role of anti‐inflammatory …
Vitamin D receptor: a new risk marker for clinical restenosis after percutaneous coronary intervention
PS Monraats, Y Fang, D Pons, NMM Pires… - Expert Opinion on …, 2010 - Taylor & Francis
Objective: Restenosis is the main drawback of percutaneous coronary intervention (PCI).
Inherited factors may explain part of the risk of restenosis. Recently, the vitamin D receptor …
Inherited factors may explain part of the risk of restenosis. Recently, the vitamin D receptor …
[HTML][HTML] Efficacy and safety of haloperidol prophylaxis for delirium prevention in older medical and surgical at-risk patients acutely admitted to hospital through the …
EJM Schrijver, OJ de Vries, A Verburg, K de Graaf… - BMC geriatrics, 2014 - Springer
Background Delirium is associated with substantial morbidity and mortality rates in elderly
hospitalised patients, and a growing problem due to increase in life expectancy …
hospitalised patients, and a growing problem due to increase in life expectancy …
p27kip1–838C>A Single Nucleotide Polymorphism Is Associated With Restenosis Risk After Coronary Stenting and Modulates p27kip1 Promoter Activity
CM Van Tiel, PI Bonta, SZH Rittersma, MAM Beijk… - Circulation, 2009 - Am Heart Assoc
Background—The cyclin-dependent kinase inhibitor p27kip1 is a key regulator of smooth
muscle cell and leukocyte proliferation in vascular disease, including in-stent restenosis. We …
muscle cell and leukocyte proliferation in vascular disease, including in-stent restenosis. We …
Interleukin 10: a new risk marker for the development of restenosis after percutaneous coronary intervention
PS Monraats, FAS Kurreeman, D Pons… - Genes & …, 2007 - nature.com
Genetic factors appear to be important in the process of restenosis after percutaneous
coronary intervention (PCI), as well as in inflammation, a pivotal factor in restenosis. An …
coronary intervention (PCI), as well as in inflammation, a pivotal factor in restenosis. An …
Platelet receptor P2RY12 haplotypes predict restenosis after percutaneous coronary interventions
G Rudež, D Pons, F Leebeek, P Monraats… - Human …, 2008 - Wiley Online Library
The platelet receptor P2Y12 (gene symbol P2RY12) is involved in several processes that
contribute to restenosis after percutaneous coronary interventions (PCI). Therefore, common …
contribute to restenosis after percutaneous coronary interventions (PCI). Therefore, common …
Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three …
D Pons, S Trompet, AJM de Craen, PE Thijssen… - Heart, 2011 - heart.bmj.com
Aims This study was designed to investigate the counterbalancing influence of genetic
variation in the promoter of the gene encoding P300/CBP associated factor (PCAF), a lysine …
variation in the promoter of the gene encoding P300/CBP associated factor (PCAF), a lysine …
Inflammation and apoptosis genes and the risk of restenosis after percutaneous coronary intervention
PS Monraats, F de Vries, LW de Jong… - Pharmacogenetics …, 2006 - journals.lww.com
Objectives Genetic factors appear to be important in the development of restenosis after
percutaneous coronary intervention, as well as in the process of inflammation, a pivotal …
percutaneous coronary intervention, as well as in the process of inflammation, a pivotal …