Deregulation of microRNA-503 contributes to diabetes mellitus–induced impairment of endothelial function and reparative angiogenesis after limb ischemia
A Caporali, M Meloni, C Völlenkle, D Bonci… - Circulation, 2011 - Am Heart Assoc
Background—Diabetes mellitus impairs endothelial cell (EC) function and postischemic
reparative neovascularization by molecular mechanisms that are not fully understood …
reparative neovascularization by molecular mechanisms that are not fully understood …
[HTML][HTML] Classical macrophage activation up-regulates several matrix metalloproteinases through mitogen activated protein kinases and nuclear factor-κB
WC Huang, GB Sala-Newby, A Susana, JL Johnson… - 2012 - journals.plos.org
Remodelling of the extracellular matrix (ECM) and cell surface by matrix metalloproteinases
(MMPs) is an important function of monocytes and macrophages. Recent work has …
(MMPs) is an important function of monocytes and macrophages. Recent work has …
Vulnerable atherosclerotic plaque metalloproteinases and foam cell phenotypes
AC Newby, SJ George, Y Ismail… - Thrombosis and …, 2009 - thieme-connect.com
Plaque rupture underlies most myocardial infarctions. Plaques vulnerable to rupture have
thin fibrous caps, an excess of macrophages over vascular smooth muscle cells, large lipid …
thin fibrous caps, an excess of macrophages over vascular smooth muscle cells, large lipid …
Dismantling of cadherin-mediated cell-cell contacts modulates smooth muscle cell proliferation
EB Uglow, S Slater, GB Sala-Newby… - Circulation …, 2003 - Am Heart Assoc
Proliferation of vascular smooth muscle cells (VSMCs) contributes to intimal thickening
during atherosclerosis and restenosis. The cadherins are transmembrane proteins, which …
during atherosclerosis and restenosis. The cadherins are transmembrane proteins, which …
Regulation of smooth muscle cell proliferation by β-catenin/T-cell factor signaling involves modulation of cyclin D1 and p21 expression
H Quasnichka, SC Slater, CA Beeching… - Circulation …, 2006 - Am Heart Assoc
We previously observed that stimulation of vascular smooth muscle cell (VSMC) proliferation
with growth factors is associated with dismantling of cadherin junctions and nuclear …
with growth factors is associated with dismantling of cadherin junctions and nuclear …
[HTML][HTML] p75NTR-dependent activation of NF-κB regulates microRNA-503 transcription and pericyte–endothelial crosstalk in diabetes after limb ischaemia
The communication between vascular endothelial cells (ECs) and pericytes in the
microvasculature is fundamental for vascular growth and homeostasis; however, these …
microvasculature is fundamental for vascular growth and homeostasis; however, these …
[HTML][HTML] Identification of the prosurvival activity of nerve growth factor on cardiac myocytes
A Caporali, GB Sala-Newby, M Meloni… - Cell Death & …, 2008 - nature.com
Neurotrophins (NTs) control neuron survival and regeneration. Recent research showed that
NTs possess cardiovascular actions. In this study, we investigated the hypothesis that the NT …
NTs possess cardiovascular actions. In this study, we investigated the hypothesis that the NT …
[HTML][HTML] PKA and Epac synergistically inhibit smooth muscle cell proliferation
RC Hewer, GB Sala-Newby, YJ Wu, AC Newby… - Journal of molecular and …, 2011 - Elsevier
Cyclic AMP signalling promotes VSMC quiescence in healthy vessels and during vascular
healing following injury. Cyclic AMP inhibits VSMC proliferation via mechanisms that are not …
healing following injury. Cyclic AMP inhibits VSMC proliferation via mechanisms that are not …
Neurotrophin p75 Receptor (p75NTR) Promotes Endothelial Cell Apoptosis and Inhibits Angiogenesis: Implications for Diabetes-Induced Impaired …
A Caporali, E Pani, AJG Horrevoets… - Circulation …, 2008 - Am Heart Assoc
Diabetes impairs endothelial function and reparative neovascularization. The p75 receptor
of neurotrophins (p75NTR), which is scarcely present in healthy endothelial cells (ECs) …
of neurotrophins (p75NTR), which is scarcely present in healthy endothelial cells (ECs) …
[HTML][HTML] Relationship of MMP-14 and TIMP-3 expression with macrophage activation and human atherosclerotic plaque vulnerability
JL Johnson, NP Jenkins, WC Huang… - Mediators of …, 2014 - hindawi.com
Matrix metalloproteinase-14 (MMP-14) promotes vulnerable plaque morphology in mice,
whereas tissue inhibitor of metalloproteinases-3 (TIMP-3) overexpression is protective …
whereas tissue inhibitor of metalloproteinases-3 (TIMP-3) overexpression is protective …