The majority of estrogen receptor (ER)-positive breast cancers are treated with endocrine
therapy. While this is effective, acquired resistance to therapies targeted against ER is a …

PARP-1 is an abundant nuclear enzyme that modifies substrates by poly (ADP-ribose)-
ylation. PARP-1 has well-described functions in DNA damage repair and also functions as a …

PIK3CA mutation frequency varies among breast cancer (BC) subtypes. Recent evidence
suggests combination therapy with the PI3K inhibitor (PI3Ki) alpelisib and endocrine therapy …

Alterations in DNA repair promote tumor development, but the impact on tumor progression
is poorly understood. Here, discovery of a biochemical circuit linking hormone signaling to …

Congenital amusia is a disorder characterized by life‐long, selective deficits in the
perception of music. This study examined pitch‐perception abilities in a group of 10 adults …

A hallmark of cancer is the deregulation of cell-cycle machinery, ultimately facilitating
aberrant proliferation that fuels tumorigenesis and disease progression. Particularly, in …

To model the heterogeneity of breast cancer as observed in the clinic, we employed an ex
vivo model of breast tumor tissue. This methodology maintained the histological integrity of …

PIK3CA mutations may have prognostic value for patients with hormone receptor-
positive/human epidermal growth factor receptor 2-negative metastatic breast cancer …

Emerging evidence demonstrates that the DNA repair kinase DNA-PKcs exerts divergent
roles in transcriptional regulation of unsolved consequence. Here, in vitro and in vivo …

Triple-negative breast cancer (TNBC) is an aggressive disease that lacks established
markers to direct therapeutic intervention. Thus, these tumors are routinely treated with …