[HTML][HTML] Fibrin clot properties in atherosclerotic vascular disease: from pathophysiology to clinical outcomes
M Ząbczyk, J Natorska, A Undas - Journal of clinical medicine, 2021 - mdpi.com
Fibrin is a major component of thrombi formed on the surface of atherosclerotic plaques.
Fibrin accumulation as a consequence of local blood coagulation activation takes place …
Fibrin accumulation as a consequence of local blood coagulation activation takes place …
Diabetes mellitus as a risk factor for aortic stenosis: from new mechanisms to clinical implications
J Natorska - Kardiologia Polska (Polish Heart Journal), 2021 - journals.viamedica.pl
Aortic stenosis (AS) is a progressive disease, with no pharmacological treatment. The
prevalence of diabetes mellitus (DM) among AS patients is higher than in the general …
prevalence of diabetes mellitus (DM) among AS patients is higher than in the general …
Increased bleeding risk in patients with aortic valvular stenosis: From new mechanisms to new therapies
J Natorska, P Mazur, A Undas - Thrombosis Research, 2016 - Elsevier
Aortic stenosis (AS), the most prevalent acquired valvular disease in the adults that requires
invasive treatment, coexists with coagulopathy, resulting in bleeding in approximately 20 …
invasive treatment, coexists with coagulopathy, resulting in bleeding in approximately 20 …
[HTML][HTML] Accumulation of advanced glycation end products (AGEs) is associated with the severity of aortic stenosis in patients with concomitant type 2 diabetes
M Kopytek, M Ząbczyk, P Mazur, A Undas… - Cardiovascular …, 2020 - Springer
Background Accumulation of advanced glycation end products (AGEs) leads to chronic
glycation of proteins and tissue damage, particularly in patients with diabetes mellitus (DM) …
glycation of proteins and tissue damage, particularly in patients with diabetes mellitus (DM) …
[HTML][HTML] Does diabetes accelerate the progression of aortic stenosis through enhanced inflammatory response within aortic valves?
J Natorska, E Wypasek, G Grudzień, D Sobczyk… - Inflammation, 2012 - Springer
Diabetes predisposes to aortic stenosis (AS). We aimed to investigate if diabetes affects the
expression of selected coagulation proteins and inflammatory markers in AS valves. Twenty …
expression of selected coagulation proteins and inflammatory markers in AS valves. Twenty …
[HTML][HTML] Prothrombotic fibrin clot properties associated with NETs formation characterize acute pulmonary embolism patients with higher mortality risk
M Ząbczyk, J Natorska, A Janion-Sadowska… - Scientific Reports, 2020 - nature.com
Venous thromboembolism is associated with formation of denser fibrin clots resistant to lysis.
We investigated whether prothrombotic plasma clot properties are associated with the …
We investigated whether prothrombotic plasma clot properties are associated with the …
The effect of DOAC-Stop on lupus anticoagulant testing in plasma samples of venous thromboembolism patients receiving direct oral anticoagulants
M Ząbczyk, M Kopytek, J Natorska… - Clinical Chemistry and …, 2019 - degruyter.com
Abstract Background Direct oral anticoagulants (DOACs) cause false positive lupus
anticoagulant (LA) results. We assessed the impact of DOAC-Stop, reversing in vitro effects …
anticoagulant (LA) results. We assessed the impact of DOAC-Stop, reversing in vitro effects …
Increased thrombin generation and platelet activation are associated with deficiency in high molecular weight multimers of von Willebrand factor in patients with …
J Natorska, K Bykowska, M Hlawaty, G Marek… - Heart, 2011 - heart.bmj.com
Background High molecular weight von Willebrand factor (vWF) multimers (HMWM) are
often deficient in patients with severe aortic stenosis (AS) owing to shear stress-enhanced …
often deficient in patients with severe aortic stenosis (AS) owing to shear stress-enhanced …
[HTML][HTML] Diabetes concomitant to aortic stenosis is associated with increased expression of NF-κB and more pronounced valve calcification
M Kopytek, P Mazur, M Ząbczyk, A Undas, J Natorska - Diabetologia, 2021 - Springer
Aims/hypothesis Type 2 diabetes has been demonstrated to predispose to aortic valve
calcification. We investigated whether type 2 diabetes concomitant to aortic stenosis (AS) …
calcification. We investigated whether type 2 diabetes concomitant to aortic stenosis (AS) …
Relations between circulating microRNAs (miR-21, miR-26, miR-29, miR-30 and miR-133a), extracellular matrix fibrosis and serum markers of fibrosis in dilated …
P Rubiś, J Totoń-Żurańska… - International Journal of …, 2017 - Elsevier
Cardiac fibrosis is a consequence of collagen overproduction and accumulation in the
extracellular matrix (ECM)[1]. Collagen biosynthesis is regulated by osteopontin (OPN) …
extracellular matrix (ECM)[1]. Collagen biosynthesis is regulated by osteopontin (OPN) …