This Review is intended to help clinicians, patients, and the public make informed decisions
about statin therapy for the prevention of heart attacks and strokes. It explains how the …

Background The increased use of meta-analysis in systematic reviews of healthcare
interventions has highlighted several types of bias that can arise during the completion of a …

Objective To systematically review the accuracy of physicians' clinical predictions of survival
in terminally ill cancer patients. Data sources Cochrane Library, Medline (1996-2000) …

Background Resectable oesophageal cancer is often treated with surgery alone or with
preoperative (neoadjuvant) chemoradiotherapy or chemotherapy. We aimed to clarify the …

Background Statins reduce LDL cholesterol and prevent vascular events, but their net effects
in people at low risk of vascular events remain uncertain. Methods This meta-analysis …

Importance Laparoscopic procedures are generally thought to have better outcomes than
open procedures. Because of anatomical constraints, laparoscopic rectal resection may not …

Background Although statin therapy reduces the risk of occlusive vascular events in people
with diabetes mellitus, there is uncertainty about the effects on particular outcomes and …

Context Patients with metastatic colorectal cancer who have KRAS codon 12–or KRAS
codon 13–mutated tumors are presently excluded from treatment with the anti–epidermal …

Summary Background Platelet glycoprotein IIb/IIIa inhibitors have been shown to reduce
cardiac complications in patients undergoing percutaneous coronary intervention. The …

Background Statin therapy has been shown to reduce major vascular events and vascular
mortality in a wide range of individuals, but there is uncertainty about its efficacy and safety …