Background The basal insulin analogues glargine and detemir have been subject to a
series of trials comparing their clinical profiles to the conventional preparation, neutral …

Type 2 diabetes mellitus is characterised by abnormal beta-cell function (present at the time
of diagnosis) that is often associated with insulin resistance. An important and consistent …

The effect of intravenous bicarbonate on the changes in intermediary metabolites during the
initial treatment of diabetic ketoacidosis was examined in 16 patients. The results were …

An overall hospital mortality rate of 3.9% was found in 929 episodes of diabetic ketoacidosis
treated in single centre over a 21‐year period. The mortality rate in the first half of the survey …

The original criteria described for euglycaemic ketoacidosis (initial blood glucose less than
16.7 mmol/l and plasma bicarbonate equal to or less than 10 mmol/l) were identified in 23 of …

The hyperglycaemia of NIDDM is associated with insulin resistance due, in part, to reduced
insulin receptor binding and more especially postreceptor defects. Metformin is an …

With growing concerns about air pollution and congestion, getting more people to move
around cities by bicycle is gaining more attention than at any point over the past 50 years. At …

The mortality rate from myocardial infarction is disproportionately high in diabetic patients.
One explanation for this may be that diabetic patients incur more extensive myocardial …

Postoperative diabetes is a reported feature of the immunosuppressive agents cyclosporin A
and FK 506. To date, however, no randomized comparative studies of the metabolic effects …

Metabolic and toxicological data were obtained during the first 24 hours following severe
and eventually fatal cyanide poisoning. Initial blood cyanide concentrations were 804 …