Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF‐1–CXCR4 axis
M Kucia, R Reca, K Miekus, J Wanzeck… - Stem …, 2005 - academic.oup.com
The α‐chemokine stromal‐derived factor (SDF)‐1 and the G‐protein–coupled seven‐span
transmembrane receptor CXCR4 axis regulates the trafficking of various cell types. In this …
transmembrane receptor CXCR4 axis regulates the trafficking of various cell types. In this …
CXCR4–SDF-1 signalling, locomotion, chemotaxis and adhesion
M Kucia, K Jankowski, R Reca, M Wysoczynski… - Journal of molecular …, 2004 - Springer
Chemokines, small pro-inflammatory chemoattractant cytokines, that bind to specific G-
protein-coupled seven-span transmembrane receptors present on plasma membranes of …
protein-coupled seven-span transmembrane receptors present on plasma membranes of …
Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication
J Ratajczak, M Wysoczynski, F Hayek… - Leukemia, 2006 - nature.com
Normal and malignant cells shed from their surface membranes as well as secrete from the
endosomal membrane compartment circular membrane fragments called microvesicles …
endosomal membrane compartment circular membrane fragments called microvesicles …
Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery
J Ratajczak, K Miekus, M Kucia, J Zhang, R Reca… - Leukemia, 2006 - nature.com
Membrane-derived vesicles (MV) are released from the surface of activated eucaryotic cells
and exert pleiotropic effects on surrounding cells. Since the maintenance of pluripotency …
and exert pleiotropic effects on surrounding cells. Since the maintenance of pluripotency …
Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer
A Janowska‐Wieczorek, M Wysoczynski… - … journal of cancer, 2005 - Wiley Online Library
The role of platelets in tumor progression and metastasis has been recognized but the
mechanism of their action remains unclear. Five human lung cancer cell lines (A549, CRL …
mechanism of their action remains unclear. Five human lung cancer cell lines (A549, CRL …
Numerous growth factors, cytokines, and chemokines are secreted by human CD34+ cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal …
M Majka, A Janowska-Wieczorek… - Blood, The Journal …, 2001 - ashpublications.org
The aim of this study was to explore further the hypothesis that early stages of normal human
hematopoiesis might be coregulated by autocrine/paracrine regulatory loops and by cross …
hematopoiesis might be coregulated by autocrine/paracrine regulatory loops and by cross …
Migration of bone marrow and cord blood mesenchymal stem cells in vitro is regulated by stromal‐derived factor‐1‐CXCR4 and hepatocyte growth factor‐c‐met axes …
BR Son, LA Marquez‐Curtis, M Kucia… - Stem …, 2006 - academic.oup.com
Human mesenchymal stem cells (MSCs) are increasingly being considered in cell‐based
therapeutic strategies for regeneration of various organs/tissues. However, the signals …
therapeutic strategies for regeneration of various organs/tissues. However, the signals …
A population of very small embryonic-like (VSEL) CXCR4+ SSEA-1+ Oct-4+ stem cells identified in adult bone marrow
M Kucia, R Reca, FR Campbell, E Zuba-Surma… - Leukemia, 2006 - nature.com
By employing multiparameter sorting, we identified in murine bone marrow (BM) a
homogenous population of rare (∼ 0.02% of BMMNC) Sca-1+ lin− CD45− cells that express …
homogenous population of rare (∼ 0.02% of BMMNC) Sca-1+ lin− CD45− cells that express …
Mobilization of CD34/CXCR4+, CD34/CD117+, c-met+ Stem Cells, and Mononuclear Cells Expressing Early Cardiac, Muscle, and Endothelial Markers Into …
W Wojakowski, M Tendera, A Michałowska, M Majka… - Circulation, 2004 - Am Heart Assoc
Background—Adult stem cells can contribute to myocardial regeneration after ischemic
injury. Bone marrow and skeletal muscles contain a population of CXCR4+ cells expressing …
injury. Bone marrow and skeletal muscles contain a population of CXCR4+ cells expressing …
STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells …
D Small, M Levenstein, E Kim… - Proceedings of the …, 1994 - National Acad Sciences
We cloned the cDNA for stem cell tyrosine kinase 1 (STK-1), the human homolog of murine
Flk-2/Flt-3, from a CD34+ hematopoietic stem cell-enriched library and investigated its …
Flk-2/Flt-3, from a CD34+ hematopoietic stem cell-enriched library and investigated its …