Extracellular vesicles (EV) consist of exosomes, which are released upon fusion of the
multivesicular body with the cell membrane, and microvesicles, which are released directly …

Renal dysfunction in heart failure with preserved ejection fraction (HFpEF) is common and is
associated with increased mortality. Impaired renal function is also a risk factor for …

In patients with end-stage renal disease (ESRD) treated with haemodialysis or peritoneal
dialysis, hypertension is common and often poorly controlled. Blood pressure (BP) …

Type 1 diabetes is associated with reduced vascular repair, as indicated by impaired wound
healing and reduced collateral formation in ischemia. Recently, endothelial progenitor cells …

Background: The healthy vascular endothelium, which forms the barrier between blood and
the surrounding tissues, is known to efficiently respond to stress signals like hypoxia and …

Signaling between endothelial cells, endothelial progenitor cells, and stromal cells is crucial
for the establishment and maintenance of vascular integrity and involves exosomes, among …

Background—The role of endothelin (ET)-1 in maintenance of basal vascular tone has been
demonstrated by local and systemic vasodilatation to endothelin receptor antagonists in …

Adult stem cell-derived organoids are three-dimensional epithelial structures that
recapitulate fundamental aspects of their organ of origin. We describe conditions for the long …

Background—Impaired nitric oxide (NO) activity is an early event in the pathogenesis of
cardiovascular disease, resulting from either reduced NO formation or increased NO …

The adult mammalian heart has limited regenerative capacity and was generally considered
to contain no dividing cells. Recently, however, a resident population of progenitor cells has …