Elucidation of the physiologically distinct subunits of troponin in 1973 greatly facilitated our
understanding of cardiac contraction. Although troponins are expressed in both skeletal and …

Extensive pre-clinical work indicates that inhibition of the sarcolemmal Na+/H+ exchanger
(NHE) affords significant protection to myocardium subjected to ischemia and reperfusion …

The p38 mitogen-activated protein kinases (p38s) are stress-activated Ser/Thr kinases. Their
activation has been associated with various pathological stressors in the heart. Activated …

BACKGROUND To test the hypothesis that the heat shock response is associated with
myocardial salvage, the heat stress protein (HSP) content of cardiac tissue was increased by …

Myocardial protection and changes in gene expression follow whole body heat stress.
Circumstantial evidence suggests that an inducible 70-kD heat shock protein (hsp70i) …

We show here that exposure of cardiac cells to simulated ischemia results in apoptosis and
is accompanied by phosphorylation and increased expression and transcriptional activity of …

Atherosclerosis and its consequences remain the main cause of mortality in industrialized
and developing nations. Plaque burden and progression have been shown to be …

Objectives: We investigated whether the source of the acute phase response in unstable
angina (UA) lay within the culprit coronary plaque or distal myocardium. Backround: An …

Perioperative myocardial ischemia contributes to postoperative morbidity and mortality.
Remote intermittent ischemia (RI) has been shown to benefit patients undergoing coronary …

Abstract Objective: Interleukin-6 (IL-6) is a pro-inflammatory cytokine which is a prognostic
marker associated with left ventricular contractile dysfunction and heart failure. On the other …