Mutations in human cause limb and cardiac malformation in Holt-Oram syndrome

CT Basson, DR Bachinsky, RC Lin, T Levi, JA Elkins… - Nature …, 1997 - nature.com
Holt-Oram syndrome is characterized by upper limb malformations and cardiac septation
defects. Here, we demonstrate that mutations in the human TBX5 gene underlie this …

Hypertensive hypertrophic cardiomyopathy of the elderly

EJ Topol, TA Traill, NJ Fortuin - New England Journal of Medicine, 1985 - Mass Medical Soc
Using echocardiography, we identified 21 patients with a syndrome that included severe
concentric cardiac hypertrophy, a small left ventricular cavity, and supernormal indexes of …

[HTML][HTML] The clinical and genetic spectrum of the Holt-Oram syndrome (heart-hand syndrome)

CT Basson, GS Cowley, SD Solomon… - … England Journal of …, 1994 - Mass Medical Soc
Background The Holt-Oram syndrome is an autosomal dominant condition characterized by
skeletal abnormalities that are frequently accompanied by congenital cardiac defects. The …

[HTML][HTML] Preclinical diagnosis of familial hypertrophic cardiomyopathy by genetic analysis of blood lymphocytes

A Rosenzweig, H Watkins, DS Hwang… - … England Journal of …, 1991 - Mass Medical Soc
Background. The clinical diagnosis of familial hypertrophic cardiomyopathy is usually made
on the basis of the physical examination, electrocardiogram, and echocardiogram. Making …

[BOOK][B] Robert Lowell, setting the river on fire: A study of genius, mania, and character

KR Jamison, TA Traill - 2017 - books.google.com
In this magisterial study of the relationship between illness and art, the best-selling author of
An Unquiet Mind, Kay Redfield Jamison, brings an entirely fresh understanding to the work …

Effect of the addition of propranolol to therapy with nifedipine for unstable angina pectoris: a randomized, double-blind, placebo-controlled trial.

SO Gottlieb, ML Weisfeldt, P Ouyang, SC Achuff… - Circulation, 1986 - Am Heart Assoc
The value of the addition of beta-blockers to coronary vasodilator therapy in the treatment of
patients with unstable angina at rest is controversial. We conducted a double-blind …

Creatine kinase adenosine triphosphate and phosphocreatine energy supply in a single kindred of patients with hypertrophic cardiomyopathy

MR Abraham, PA Bottomley, VL Dimaano… - The American journal of …, 2013 - Elsevier
A lethal and extensively characterized familial form of hypertrophic cardiomyopathy (HC) is
due to a point mutation (Arg403Gln) in the cardiac β-myosin heavy chain gene. Although this …

Valvular heart disease and pregnancy

TA Traill - Cardiology clinics, 2012 - Elsevier
Among women with valvular heart disease, those with mitral stenosis carry the greatest
potential for problems during pregnancy. Asymptomatic women with aortic stenosis and only …

Left ventricular relaxation and filling in hypertrophic cardiomyopathy. An echocardiographic study.

JE Sanderson, TA Traill, MG Sutton, DJ Brown… - Heart, 1978 - heart.bmj.com
Echocardiograms showing left ventricular cavity and mitral valve cusps simultaneously were
recorded in 36 patients, apex cardiograms being obtained in 26 of them. These were …

Abnormalities of dynamic ventricular shape change in patients with aortic and mitral valvular regurgitation: assessment by Fourier shape analysis and global …

DA Kass, TA Traill, M Keating, PI Altieri… - Circulation …, 1988 - Am Heart Assoc
The normal cardiac cycle is associated with dynamic changes in left ventricular shape,
which can be disturbed in disease states. To assess the influences of diastolic volume …