The EGF-receptor is frequently mutated in a large variety of tumors. Here we review the most
frequent mutations and conclude that they commonly enhance the intrinsic tyrosine kinase …

Chemotherapy‐and radiotherapy‐induced oral mucositis represents a therapeutic challenge
frequently encountered in cancer patients. This side effect causes significant morbidity and …

Objective Patients with cancer may display elevated levels of B-type natriuretic peptide
(BNP) and high-sensitive troponin T (hsTnT) without clinical manifestation of cardiac …

PURPOSE: Our purpose was to evaluate the 3-year clinical results of patients with medial-
compartment osteoarthritis of the knee and varus malalignment who underwent open-wedge …

Purpose: p95HER2 is an NH2-terminally truncated form of HER2 that lacks the trastuzumab
binding site and is therefore thought to confer resistance to trastuzumab treatment. In this …

Transcriptional responses to extracellular stimuli involve tuning the rates of transcript
production and degradation. Here, we show that the time‐dependent profiles of these rates …

Purpose: The present pilot study was performed to elucidate whether early changes in
serum Her-2/neu extracellular domain (ECD) levels during trastuzumab-based treatment …

Breast cancer is the most common female malignancy in many industrialized countries.
Approximately one fourth of all women diagnosed with early breast cancer present with …

The receptor tyrosine kinase HER2 is overexpressed in approximately 25% of breast
cancers. HER2 acts as a signal amplifier for its siblings, namely three different …

BACKGROUND. Previous reports based on small patient numbers suggested that changes
in serum HER‐2/neu levels may predict response or lack of response to trastuzumab‐based …