The integrin α v β 3 receptor is upregulated on tumor cells and endothelium and plays
important roles in angiogenesis and metastasis. Arg-Gly-Asp (RGD) peptide ligands have high …

There is an unmet need to develop imaging methods for the early and objective assessment
of breast tumors to therapy. 3′-Deoxy-3′-[ 18 F]fluorothymidine ([ 18 F]FLT)–positron …

Purpose: To evaluate the accuracy and biological basis for [ 11 C]choline-PET-CT in the
nodal staging of high risk localized prostate cancer patients. Experimental Design: Twenty-eight …

Resistance to 5-Fluoruracil (5-FU) has been linked to elevated expression of the main target,
thymidylate synthase (TYMS), which catalyses the de novo pathway for production of …

The objective of this study was to establish the repeatability and reproducibility limits of
several volume-related PET image–derived indices—namely tumor volume (TV), mean …

FOXM1 is implicated in genotoxic drug resistance but its role and mechanism of action
remain unclear. Here, we establish that γH2AX foci, indicative of DNA double-strand breaks (…

Effective anticancer therapy induces tumor cell death through apoptosis. Noninvasive monitoring
of apoptosis during therapy may provide predictive outcome information and help tailor …

Background Brain metastases are common in human epidermal growth factor receptor (Her)-2-positive
breast cancer. Drug access to brain metastases and normal brain is key to …

Purpose: To establish biomarkers indicating clinical response to taxanes, we determined
whether early changes in [ 18 F]-3′deoxy-3′-fluorothymidine positron emission tomography (…

We report the safety, biodistribution, and internal radiation dosimetry of a new PET tracer,
18 F-AH111585, a peptide with a high affinity for the α v β 3 integrin receptor involved in …