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The association between apnoea-hypopnoea index and flow-mediated dilation of brachial artery
  1. Silje K Namtvedt1,2,3,
  2. Jonny Hisdal4,
  3. Anna Randby1,2,3,
  4. Stefan Agewall3,5,
  5. Helge Røsjø1,2,3,
  6. Torbjørn Omland1,2,3
  1. 1 Division of Medicine, Akershus University Hospital, Lørenskog, Norway
  2. 2 K.G. Jebsen Cardiac Research Centre and Center for Heart Failure Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
  3. 3 University of Oslo, Oslo, Norway
  4. 4 Section of Vascular Investigations, Oslo Vascular Centre, Oslo University Hospital Aker, Oslo, Norway
  5. 5 Department of Cardiology, Oslo University Hospital Ullevål, Oslo, Norway
  1. Correspondence to Professor Torbjørn Omland, Department of Cardiology, Division of Medicine, Akershus University Hospital, Sykehusveien 27, Lørenskog 1478, Norway; torbjorn.omland{at}

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The Author's reply: We appreciate Dr Kawada's1 interest in our article entitled ‘Impaired endothelial function in persons with obstructive sleep apnoea: impact of obesity’ recently published in Heart.2 Dr Kawada raises several questions concerning the statistical methods used in our article and the appropriateness of using these methods.

Dr Kawada's first question concerns the distribution of variables and the use of linear regression analysis. As reported in our article,2 we checked the distribution of all variables by normal quantile-quantile plots and histograms. Relevant to the linear regression model, age and apnoea-hypopnoea index (AHI) were not normally distributed. However, the inclusion of these non-normally distributed variables …

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  • Funding This study was supported by the South-Eastern Norway Regional Health Authority (grant number 2004219 and 2789062) and the University of Oslo, Oslo, Norway. Sponsors had no role in the study design, collection, analysis and interpretation of the data, writing of the report, or the decision to submit the manuscript for publication.

  • Competing interests None.

  • Ethics approval Regional Ethics Committee of South-Eastern Norway.

  • Provenance and peer review Commissioned; internally peer reviewed.

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