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Heartbeat: Highlights from this issue
  1. Catherine M Otto
  1. Correspondence to Professor Catherine M Otto, Division of Cardiology, University of Washington, Seattle, WA 98195, USA; cmotto{at}

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Exercise and the heart is the focus of two original research articles in this issue of Heart. The first paper, by Dr Mons and colleagues (see page 1043) examined the dose-response curve between self-reported physical activity levels and prognosis in a prospective cohort of 1039 subjects with stable coronary disease. Graphs of the level of physical activity versus clinical outcomes of major cardiovascular events, nonfatal cardiovascular events, cardiovascular and all cause mortality, all showed that the highest risk was seen for inactive patients, however risk also was higher in those with high levels of physical activity compared to those who exercise only 2 to 4 hours per week (see figure 1).

Figure 1

Relationship between overall duration of strenuous activity in hours per week and cardiovascular mortality. Solid black line: point estimates; grey dashed lines: 95% CIs. The black circles in the point estimates curve represent the knots, which were set at the 5th, 50th and 95th percentiles according to the distributions …

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