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Ischaemic heart disease
Clinical implications of the Third Universal Definition of Myocardial Infarction
  1. Harvey D White1,
  2. Kristian Thygesen2,
  3. Joseph S Alpert3,
  4. Allan S Jaffe4
  1. 1Cardiology Department, Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand
  2. 2Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
  3. 3Department of Medicine, University of Arizona College of Medicine, Tucson, Arizona, USA
  4. 4Cardiovascular Division, Department of Medicine, Laboratory Medicine and Pathology, Mayo Clinic and Medical School, Rochester, Minnesota, USA
  1. Correspondence to Professor Harvey D White, Cardiology Department, Green Lane Cardiovascular Service, Auckland City Hospital, Private Bag 92024, Victoria St West, Auckland 1142, New Zealand; HarveyW{at}

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The definition of myocardial infarction (MI) continues to evolve as refined ECG criteria, more advanced imaging, and more sensitive and specific biomarkers are developed. The acceptance globally of a clinically practical standard definition for everyday practice would allow for better comparisons across clinical experiences and further facilitate research in this critical area. Because of the evolution of better diagnostic tools and more information about the value and limitations of previous definitions, there was a need to update the Universal Definition of MI published in 20071 and this has recently been accomplished.2 Great efforts were made by the taskforce that developed these guidelines to establish clinical criteria which correspond to the contemporary management of patients suspected of having MI. Therefore, a combination of clinical symptoms, cardiac biomarkers, and ECG changes indicative of myocardial ischaemia are central to the 2012 Third Universal Definition of MI. It stresses the importance of a careful clinical history of 20 min of ischaemic symptoms which may not be classical chest discomfort in all instances, an appreciation of the clinical setting (eg, in the critically ill), and careful interpretation of the ECG. Biomarkers are central to the diagnosis, and imaging has received more emphasis (box 1).

Box 1

Definition of myocardial infarction (MI)

  • Criteria for acute myocardial infarction

  • The term acute myocardial infarction (AMI) should be used when there is evidence of myocardial necrosis in a clinical setting consistent with acute myocardial ischaemia. Under these conditions, any one of the following criteria meets the diagnosis for MI:

  • Detection of a rise and/or fall of cardiac biomarker values (preferably cardiac troponin) with at least one value above the 99th centile upper reference limit (URL) and with at least one of the following:

  •   – Symptoms of ischaemia

  •   – New or presumed new significant ST segment-T wave (ST-T) changes or …

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  • Contributors All authors have made substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data. All authors have been involved in drafting the article or revising it critically for important intellectual content, and all authors have given final approval of the version to be published.

  • Competing interests In compliance with EBAC/EACCME guidelines, all authors participating in Education in Heart have disclosed potential conflicts of interest that might cause a bias in the article. HW has received research grants from: Sanofi Aventis; Eli Lilly; Medicines Company; NIH; Pfizer; Roche; Johnson & Johnson; Schering Plough; Merck Sharpe & Dohme; Astra Zeneca; GlaxoSmithKline; Daiichi Sankyo Pharma Development and Bristol-Myers Squibb, and has served on advisory boards for Merck Sharpe & Dohme, Roche and Regado Biosciences. KT has received lecture honoraria from Roche Diagnostics. JSA has received Consultation and Data Safety and Monitoring honoraria from Servier pharma, Johnson & Johnson, Bayer, Daiichi Sankyo Pharma, Sanofi Aventis, Bristol Myers Squibb, Elsevier Publishers, and UptoDate. AJ has consulted or presently consults for most of the major diagnostic companies. At present these include Roche, Alere, Abbott Ortho, Critical Diagnostics, and Radiometer. He also consults for Amgen.

  • Provenance and peer review Commissioned; externally peer reviewed.

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