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Stent thrombosis in early-generation drug-eluting stents versus newer-generation everolimus-eluting stent assorted by LVEF
  1. Nick van Boven1,2,
  2. Stephan Windecker3,
  3. Victor A Umans1,
  4. Ron T van Domburg4,
  5. Isabella Kardys4,
  6. K Martijn Akkerhuis4,
  7. Robbert-Jan van Geuns4,
  8. Patrick W Serruys4,
  9. Michael Magro4,
  10. Lorenz Räber3,
  11. Eric Boersma4
  1. 1Department of Cardiology, Medical Centre Alkmaar, Alkmaar, The Netherlands
  2. 2Cardiovascular Research School (COEUR), Erasmus university, Rotterdam, The Netherlands
  3. 3Department of Cardiology, Bern University Hospital, Bern, Switzerland
  4. 4Erasmus MC, Rotterdam, The Netherlands
  1. Correspondence to Professor Eric Boersma, Erasmus MC, Rotterdam, room Bd381 's Gravendijkwal 230, Rotterdam 3015 CE, The Netherlands; h.boersma{at}


Objective Everolimus drug-eluting stents (EES) are superior to early-generation drug-eluting stents (DES), releasing sirolimus (SES) or paclitaxel (PES) in preventing stent thrombosis (ST). Since an impaired LVEF seems to increase the risk of ST, we aimed to investigate the difference in outcome of patients with varying LVEF using EES versus early-generation DES.

Methods In a prospective cohort study, we compared the risk of ST in patients in three LVEF subgroups: normal (LVEF >50%), mildly impaired (LVEF >40% and ≤50%) and moderate–severely impaired (LVEF ≤40%). Within these various LVEF groups, we compared EES with SES and PES after adjustment for baseline differences.

Results We assessed a cohort of 5363 patients, with follow-up of up to 4 years and available LVEF. Overall definite ST occurred in 123 (2.3%) patients. ST rates were higher in the LVEF moderate–severely impaired group compared with the normal LVEF group (2.8% vs 2.1%; HR 1.82; CI 1.10 to 3.00). Especially early ST (EST) was more frequent in the moderate–severely impaired LVEF group (HR 2.20; CI 1.06 to 4.53). Overall rates of definite ST were lower in patients using EES compared with patients using SES or PES in all LVEF groups. Interaction terms were not statistically significant. ST rates were higher in the moderate–severely impaired LVEF group compared with the normal LVEF group when using SES or PES, but not significantly different when using EES.

Conclusions EES was associated with a lower risk of definite ST compared with early-generation DES. This lower risk was independent of LVEF, even though ST rates were higher in patients with a moderate–severely impaired LVEF.

Trial registration no MEC-2013-262.

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