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Footnotes
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Contributors VM-S, RPW and CDG were involved in the writing and initial critical review of the manuscript. MSM, SRR and TP were involved in subsequent critical review.
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Funding British Heart Foundation Clinical Training Fellowship awarded to Dr Williams grant number FS/11/90/29087. National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas’ National Health Service Foundation Trust and King's College London.
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Competing interests None.
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Provenance and peer review Commissioned; externally peer reviewed.