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Higher circulating adiponectin levels are associated with increased risk of atrial fibrillation in older adults
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Other responses

  • Published on:
    The enigma of high adiponectin levels and adverse outcomes in older people: a consequence of proinflammatory state and autoimmune activation?
    • Altan Onat, Altan Onat
    • Other Contributors:
      • Gunay Can, Evin Ademoglu

    The excellently analyzed paper from the Cardiovascular Health Study on higher circulating adiponectin being associated with elevated risk of atrial fibrillation (AF) in the elderly [1), calls for focusing attention on this and analogous paradoxical manifestations accumulating in the medical literature. The investigation by Macheret and associates involved 886 incident AF events in a cohort of older -predominantly female-...

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    Conflict of Interest:
    None declared.
  • Published on:
    Adiponectin and Atrial Fibrillation in Older Adults

    We thank Dr. Kawada for his comments regarding our study. Consistent with the sexual dimorphism in circulating adiponectin levels documented in both rodents and humans, plasma concentrations of total and high-molecular -weight (HMW) adiponectin were higher in female than male participants in the Cardiovascular Health Study.[1] Despite such differences, we have not found evidence of effect modification by sex for total or H...

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    Conflict of Interest:
    None declared.
  • Published on:
    Total and high molecular weight adiponectin are positively associated with incident atrial fibrillation by a follow-up study

    I read with great interest the report by Macheret et al., (1) who conducted an 11-year prospective study in 3190 older adults, aged 65 years or older, without cardiovascular disease for monitoring incident atrial fibrillation (AF). The authors measured plasma total adiponectin, high molecular weight (HMW) adiponectin and amino-terminal pro-brain natriuretic peptide 1-76 (NT-proBNP1-76). There were 886 incident AF events,...

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    Conflict of Interest:
    None declared.