Article Text
Statistics from Altmetric.com
The cardiotoxic effects of some chemotherapeutic regimens are well known and we all recognize the need for periodic cardiac monitoring in patients receiving these agents. The possibility of subclinical myocardial damage associated with cancer itself is less well established. In this issue of Heart (see page 1874), a study by Pavo and colleagues of 555 consecutive oncology patients demonstrated that elevated circulating levels of cardiovascular peptides were present prior to the start of any cancer therapy. In addition, they report the important novel finding that elevated cardiovascular peptide levels were significant predictor of all-cause mortality (34%) at median followup of 25 months. Biomarkers that were independently predictive of mortality included N-terminal pro-B-type natriuretic peptide (HR 1.54, IQR 1.24–1.90), mid-regional pro-adrenomedullin, C-terminal pro-endothelin-1, copeptin, and high sensitivity troponin T (HR 1.21, IQR 1.13–1.32) (figure 1).
In the accompanying editorial, Dr Lyon …
Linked Articles
- Cardiac risk factors and prevention
- Editorial
- Heart failure and cardiomyopathies
- Editorial
- Heart failure and cardiomyopathies
- Editorial
- Education in Heart