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Cochrane corner: exercise for people with high cardiovascular risk
  1. Pamela Serón1,
  2. Héctor Pardo2,
  3. Fernando Lanas1
  1. 1Departament of Internal Medicine, Center of Excellence CIGES, Universidad de La Frontera, Temuco, Chile
  2. 2Iberoamerican Cochrane Centre, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain
  1. Correspondence to Dr Pamela Serón, Internal Medicine Departament, CIGES, Universidad de La Frontera, Claro Solar 115—Of 304, Temuco 4781176, Chile; pamela.seron{at}

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Physical inactivity accounts for 3.3% of deaths and 19 million disability-adjusted life years worldwide.1 It has been shown that regular physical activity is a protective factor associated with myocardial infarction (OR 0.86, 95% CI 0.76 to 0.97), reducing population attributable risk by 12%.2 Physical activity during adulthood can increase total life expectancy and life expectancy free of cardiovascular disease between 1.3 and 3.5 years.3

From the point of view of primary prevention, emphasis to control cardiovascular risk factors such as hypertension, dyslipidemia and type II diabetes is fundamentally related to pharmacological interventions. As a result, measures to control underlying factors, such as diet and physical activity, are often overlooked. However, these underlying factors, given their pleiotropic effects, influence both established and emerging risk factors,4 ,5 making them invaluable tools for the primary prevention of cardiovascular and chronic conditions. Exercise raises high-density lipoprotein (HDL) cholesterol; lowers low-density lipoprotein (LDL) cholesterol, triglycerides and blood pressure; improves fasting and postprandial glucose-insulin homeostasis; maintains and induce …

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  • Contributors PS drafted the manuscript. HP and FL revised the manuscript for its intellectual content. All authors contributed substantially to this manuscript and have approved the final version.

  • Competing interests None.

  • Provenance and peer review Commissioned; internally peer reviewed.