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    Risks of NSAID Use after Myocardial Infarction

    Nonsteroidal anti-inflammatory drugs (NSAID) are frequently used as over-the-counter and prescription medications. Although prior studies have raised concern about the cardiovascular safety of these medications, detailed information on the risk of these medications in patients after myocardial infarction (MI) is lacking. In this study, retrospective Danish National Patient Registry data was evaluated for all patients >30 years old, admitted with first myocardial infarction (MI) between 2002–2011 and who survived to 30 days post-discharge. All claimed medications were identified for anti-platelet agents and NSAIDS and evaluated as a time-varying covariate in the analysis to ensure outcomes were properly allocated when patients were or were not exposed. Importantly, the only over-the-counter NSAID available in Denmark is ibuprofen at low doses, thus reducing potential misclassification …

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