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Contributors WHWT drafted the editorial and SLH critically reviewed and edited the final version.
Funding Supported by grants from the National Institutes of Health and the Office of Dietary Supplements (R01HL103866, P20HL113452 and R01DK10600).
Competing interests SLH are named as coinventor on pending patents held by the Cleveland Clinic relating to cardiovascular diagnostics and therapeutics. SLH reports having been paid as a consultant for the following companies: Esperion and P&G. SLH reports receiving research funds from Abbott, P&G, Pfizer, Roche Diagnostics and Takeda. SLH reports having the right to receive royalty payments for inventions or discoveries related to cardiovascular diagnostics or therapeutics from the following companies: Cleveland Heart Lab, Siemens, Esperion and Frantz Biomarkers LLC.
Provenance and peer review Commissioned; internally peer reviewed.