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Contributors PAG and UST are involved in both designing and writing this manuscript.
Competing interests PAG reports serving as a consultant fees/receiving honoraria from Daiichi Sankyo, Bayer, AstraZeneca, Merck, Boehringer, New Haven Pharmaceuticals, Janssen and CSL; receiving grants from the National Institutes of Health, Daiichi Sankyo/Lilly, New Haven Pharmaceuticals, Harvard Clinical Research Institute, Bayer, Haemonetics, Duke Clinical Research Institute, Sinnowa and Coramed.
Provenance and peer review Commissioned; externally peer reviewed.
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