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Progression of aortic regurgitation after subpulmonic infundibular ventricular septal defect repair
  1. Masashi Amano1,
  2. Chisato Izumi1,
  3. Sari Imamura1,
  4. Naoaki Onishi1,
  5. Yodo Tamaki1,
  6. Soichiro Enomoto1,
  7. Makoto Miyake1,
  8. Toshihiro Tamura1,
  9. Hirokazu Kondo1,
  10. Kazuaki Kaitani1,
  11. Kazuo Yamanaka2,
  12. Yoshihisa Nakagawa1
  1. 1Department of Cardiology, Tenri Hospital, Tenri, Japan
  2. 2Department of Cardiovascular Surgery, Tenri Hospital, Tenri, Japan
  1. Correspondence to Dr Chisato Izumi, Department of Cardiology, Tenri Hospital, 200 Mishima-cho, Tenri, Nara 632-8552, Japan; izumi-ch{at}


Objective In patients with subpulmonic infundibular ventricular septal defect (VSD), postoperative progression of aortic regurgitation (AR) sometimes occurs despite early operation before the development of AR. The present study was aimed to identify the occurrence rate and predictors of late AR progression after VSD repair alone.

Methods We retrospectively investigated 91 consecutive patients who underwent subpulmonic infundibular VSD repair alone and were followed up with echocardiography for >3 years postoperatively. The clinical backgrounds and chronological changes in postoperative AR were evaluated.

Results The median follow-up period after VSD repair was 13.4 years. Among 91 patients, 7 patients showed postoperative AR progression (AR progression group) and 84 patients did not (No AR progression group). No patient in AR progression group revealed more than moderate AR preoperatively. The incidence of postoperative VSD leakage was significantly higher in AR progression group than No AR progression group (43.0% vs 2.4%, respectively; p<0.01). No significant differences were present in sex, age, preoperative AR severity, VSD diameter or rate of cusp herniation. All patients in AR progression group showed deformity of the right coronary cusp or leaflet, resulting in AR progression.

Conclusions Among patients with subpulmonic infundibular VSD, the incidence of late AR progression after VSD repair alone was unexpectedly high (7.7%). Postoperative VSD leakage may be a significant risk factor for late AR progression. Long-term follow-up of postoperative AR is needed even for patients who undergo VSD repair alone.

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