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A novel troponin I rule-out value below the upper reference limit for acute myocardial infarction
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    Response: A novel troponin I rule-out value below the upper reference limit for acute myocardial infarction
    • Andrew R. Chapman, Clinical Research Fellow
    • Other Contributors:
      • Atul Anand, Anoop SV Shah, Philip D Adamson, Nicholas L Mills

    To the Editor,

    Goorden et al aim to establish the optimal threshold to rule out myocardial infarction using a high-sensitivity cardiac troponin I assay. They report that a cardiac troponin I concentration <10 ng/L or a change of <20 ng/L on serial testing had a negative predictive value for the diagnosis of myocardial infarction of 99.8% and 98.7% respectively [1]. Whilst we agree there are better appro...

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    Conflict of Interest:
    None declared.