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To recognise spontaneous coronary artery dissection (SCAD) as a cause of myocardial infarction in low-risk, predominantly female, patients and to understand that although SCAD is an important cause of peripartum myocardial infarction, ~90% of incident cases are not pregnant.
To be aware that a visible dissection flap at angiography is absent in the majority of cases.
To understand the rationale for an ‘as conservative as possible’ approach to revascularisation and key challenges in medical treatment.
Spontaneous coronary artery dissection (SCAD) is an increasingly recognised cause of non-atherosclerotic acute coronary syndromes leading to myocardial infarction. It is characterised by the presence of blood entering and separating the layers of the coronary arterial wall to form a false lumen. This leads to external compression of the true coronary lumen restricting coronary blood flow and leading to coronary insufficiency (figure 1). SCAD should be distinguished from atherosclerotic dissections arising from plaque rupture events or erosions allowing blood to enter the intimal space and from iatrogenic dissections arising during coronary procedures.
The true incidence of SCAD is unknown, largely because most patients fall into the lowest risk categories for conventional atherosclerotic disease leading to underdiagnosis and probably lower rates of presentation by patients.1 Historically thought to be very rare, increasing use of high-sensitivity troponin with early angiography for the assessment of acute chest pain presentations has led to a greater recognition of SCAD. However, accurate angiographic diagnosis can be challenging and reported rates of SCAD diagnosis from angiographic registries (0.2%–0.7% of angiograms; 2.0% of ACS angiograms) …
Contributors All authors have contributed to the preparation, refinement and review of the article and are in agreement with its content.
Funding This work is supported by the Department of Cardiovascular Sciences at the University of Leicester, the NIHR Leicester Cardiovascular Biomedical Research Unit, the NIHR rare diseases translational research collaboration and the British Heart Foundation.
Competing interests None declared.
Provenance and peer review Commissioned; externally peer reviewed.
Collaborators The ESC-ACCA Spontaneous Coronary Artery Dissection Study Group: Fernando Alfonso, Angela Maas, Christiaan Vrints, Tom W Johnson, Stephen P Hoole, Nilesh J Samani, Gerry P McCann.