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Original research article
Nitric oxide synthase inhibition restores orthostatic tolerance in young vasovagal syncope patients
  1. Julian M Stewart1,2,
  2. Richard Sutton3,
  3. Mira L Kothari1,
  4. Amanda M Goetz1,
  5. Paul Visintainer4,
  6. Marvin Scott Medow1,2
  1. 1 Departments of Pediatrics, New York Medical College, Valhalla, New York, USA
  2. 2 Departments of Physiology, New York Medical College, Valhalla, New York, USA
  3. 3 The National Heart & Lung Institute, Imperial College, London, UK
  4. 4 Baystate Medical Center, University of Massachusetts School of Medicine 4, Springfield MA, USA
  1. Correspondence to Professor Julian M Stewart, New York Medical College, Center for Hypotension 19 Bradhurst Ave, Suite 1600S, Hawthorne, New York 10532; julian_stewart{at}nymc.edu

Footnotes

  • Contributors JMS was responsible for the conception and design of the experiments, interpretation of data and drafting the article. RS was responsible for interpretation of the data and revising the manuscript. MLK was responsible for collection, assembly and interpretation of the data. AMG was responsible for collection, assembly and interpretation of the data. PV was responsible for biostatistical analysis and interpretation of the data and critically revising intellectual content of the article. MSM was responsible for design of the experiments, analysis and interpretation of the data and critically revising intellectual content of the article. All authors read and approved the final article.

  • Funding Funding for this project was provided by National Institutes of Health grant RO1 HL 112736 (JMS) and NIH R21NS 094644 (MSM).

  • Competing interests None declared.

  • Patient consent Consent for our research were signed by patient, and by guardian if under 18 years old. However, the data presented here are completely anonymized.

  • Ethics approval Committee for the Protection of Human Subjects of New York Medical College.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • Contributors JMS was responsible for the conception and design of the experiments, interpretation of data and drafting the article. RS was responsible for interpretation of the data and revising the manuscript. MLK was responsible for collection, assembly and interpretation of the data. AMG was responsible for collection, assembly and interpretation of the data. PV was responsible for biostatistical analysis and interpretation of the data and critically revising intellectual content of the article. MSM was responsible for design of the experiments, analysis and interpretation of the data and critically revising intellectual content of the article. All authors read and approved the final article.

  • Funding Funding for this project was provided by National Institutes of Health grant RO1 HL 112736 (JMS) and NIH R21NS 094644 (MSM).

  • Competing interests None declared.

  • Patient consent Consent for our research were signed by patient, and by guardian if under 18 years old. However, the data presented here are completely anonymized.

  • Ethics approval Committee for the Protection of Human Subjects of New York Medical College.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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