Objective Exercise-induced cardiac dysfunction and corollary biomarker release have been documented following long-distance running events. To what degree these processes occur during shorter distance running events is unknown.
Methods 72 healthy recreational runners (54% male/46% female) recruited by age (group 1 (18–20 years old, N=19); group 2 (45–50 years old, N=27); group 3 (70–75 years old, N=26)) were studied with echocardiography and biochemical profiling during participation in a 10 km running race.
Results Despite age-dependent baseline differences in ventricular size and diastolic tissue velocities, there were no significant within group or across group decrements in ventricular systolic or diastolic function following race completion. Postrace increases in cardiac troponin-I (cTnI), B-type natriuretic peptide (BNP) and high-sensitivity C-reactive protein (hs-CRP) were common and demonstrated distinct age dependent profiles. Specifically, BNP increases were most pronounced among older runners (group 3Δ: 16±22 pg/mL, p=0.001), hs-CRP increased only among younger runners (group 1Δ: 1.5±2.7 mg/L, p=0.03) and cTnI increased in both younger (group 1Δ: 0.01±0.02 ng/mL, p=0.028) and older (group 3Δ: 0.01±0.01 ng/mL, p=0.007) runners, but not middle aged runners (group 2Δ: 0.00±0.00 ng/mL, p=0.57).
Conclusions Moderate distance recreational running leads to distinct age-dependent biomarker release but is not associated with cardiac fatigue, a proposed stimulus for pathologic cardiac remodelling that has been observed following longer distance running events.
Statistics from Altmetric.com
Twitter Follow Jonathan Kim at @jonathankimmd
Contributors JHK contributed to study design, data acquisition, data analysis, data interpretation, drafting of manuscript, critical revisions and final approval and accountability of work. Y-AK, LSS and ALB contributed to study design, data analysis, data interpretation, drafting of manuscript, critical revisions and final approval of work. JH, JM, MA, WT, SH and HA contributed to study design, data acquisition, drafting of manuscript, critical revisions and final approval of work. N-AL and PWW contributed to study design, data analysis, drafting of manuscript, critical revisions and final approval of work. MW and JSW Jr contributed to study design, data acquisition, data interpretation, drafting of manuscript, critical revisions and final approval of work.
Funding JHK is supported by the National Institutes of Health (K23 HL128795).
Competing interests None declared.
Ethics approval Emory University Institutional Review Board.
Provenance and peer review Not commissioned; externally peer reviewed.
Data sharing statement All relevant data from this original study have been shared in the current submission.
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.