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135 Sources of streptococcal bacteraemia and their implications for the diagnosis of infective endocarditis
  1. Louis Baig,
  2. Mirza Wazir Baig,
  3. Jonathan Sandoe
  1. Leeds Teaching Hospital Trusts


Introduction The diagnosis of infective endocarditis (IE) is dependent on the detection of a sustained bacteraemia with multiple positive blood cultures being major criteria in the Duke nosology for IE. The interpretation of a single positive blood culture growing pathogens that could cause IE, but that do not fulfil major Duke criteria, is a common diagnostic difficulty in patients with a febrile illness. This study was designed to examine the clinical outcomes in patients with streptococcal bacteraemias and to determine the proportion of these with a final diagnosis of IE.

Methods This was a retrospective descriptive analysis of patients with streptococcal bacteraemias between September-December 2012. IE was confirmed by a Consultant Microbiologist (JS) using the modified Duke criteria. The variables recorded were age, gender, number of blood cultures taken and the final diagnosis stated in the discharge summary.

Results 112 episodes were identified in 72 females and 40 males (mean age 40 years, range<1–97). The mean number of blood cultures was 2.57 (range1-12) and 85 (76%) patients had only one blood culture taken. The infections recorded are shown in Figure 1. The cause of the bacteraemia was not stated in 33 (29.5%) cases. Community acquired pneumonia (n=31) was the commonest infection, followed by catheter-related bloodstream infection (n=8) and then IE and soft-tissue infection (both n=7). Details of the streptococcal species are shown in Table 1 and the results have been divided using age less than or greater than 18 years. 50% of bacteraemias were caused by oral streptococci. IE was confirmed in only 7 (1.2%).

Conclusions Among all streptococcal bacteraemias, IE is an uncommon cause but is more common when considering oral streptococci in adults (12.5%) compared with those aged less than 18 years (0%). Oral streptococci remain an important cause of IE particularly in adults. This diagnosis should be considered even if only one blood culture is taken and is positive. The high rate of single blood culture sampling (76%) may be an unintended consequence of the Surviving Sepsis campaign and the drive to initiating empirical antibiotic therapy earlier. Under these circumstances the reliability of the Duke criteria will be reduced. Ideally, patients at increased risk of IE require multiple blood cultures if they have a significant pyrexial illness in order to determine if a sustained bacteraemia is present.

  • endocarditis
  • bacteraemia
  • sepsis

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