Article Text

Download PDFPDF

54 Frail older patients have a greater improvement in physical quality of life than robust patients at one year following invasive treatment for non-st elevation acute coronary syndrome
  1. Hannah Sinclair1,
  2. Sophie Zhaotao Gu2,
  3. Jonathan Batty2,
  4. Benjamin Beska2,
  5. Murugapathy Verrasamy1,
  6. Gary Ford3,
  7. Weiliang Qiu4,
  8. Vijay Kunadian2
  1. 1Institute of Cellular Medicine, Newcastle University, and Cardiothoracic Centre, Freeman Hospital
  2. 2Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University
  3. 3Divison of Medical Sciences, Oxford University
  4. 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital/Harvard Medical School


Introduction Frailty, a vulnerability to physiological stressors due to a decline in reserve with age, is common in older patients who present with non-ST elevation coronary syndrome (NSTEACS) and is associated with a disproportionately high morbidity and mortality. We aimed to determine how frailty influences physical quality of life (QoL) outcomes after invasive treatment for NSTEACS.

Methods From February 2013 to April 2015, 232 patients aged 75 years with NSTEACS were enrolled into a multicentre prospective observational study. Frailty was assessed using the Fried criteria, where a score of 0 is robust, 1 or 2 is pre-frail and 3 is frail. QoL was evaluated using the Short Form-36 (SF-36) questionnaire (license number QM033917) at baseline and 1 year follow-up. The norm-based Physical Component Score (PCS), an aggregated summary score of the 8 SF-36 subscales, is reported.

Results Mean age was 81±4 years, 60% were male and 88% received invasive treatment (percutaneous coronary intervention or coronary artery bypass grafting). At presentation, 39 (16.8%) patients were robust, 123 (53%) were pre-frail and 70 (30.2%) were frail. Increasing frailty was associated with decreased physical QoL at both baseline and 1 year (p<0.001 for both time points). Although all frailty groups saw an increase in mean PCS, this difference was only statistically significant in frail patients (robust: 42.4±11.4 to 44.3±12.4, p=0.372; pre-frail: 38.4±11.4 to 41.6±11.7, p=0.117; frail: 27.2±8.1 to 32.9±12.7, p=0.015). In addition, only frail patients who received invasive treatment saw this significant increase in PCS between baseline and 1 year, although numbers receiving medical therapy was low (Figure 1).

Conclusion Although frail older patients with NSTEACS have a poorer physical QoL overall, our data suggest frailty is associated with a similar or greater improvement from baseline QoL in those who receive invasive treatment.

Abstract 54 Figure 1

Change In PCS By Frailty And Treatment

  • frailty
  • quality of life
  • acute coronary syndrome

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.