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Healthcare costs for patients with chronic heart failure (CHF) account for 2% of the UK National Health Service budget so that efforts to improve outcomes and reduce hospitalisations in this patient group is relevant to healthcare policy. However, the reasons for recurrent hospitalisation in CHF patients are not well understood. In order to assess whether socioeconomic deprivation, measured by the UK Index of Multiple Deprivation (IMD), contributes to adverse outcomes in CHF patients, Witte and colleagues1 analysed data from a prospective cohort of 1802 CHF patients (ejection fraction 45% or less) followed for a mean of 4 years. The IMD score was associated with non-cardiovascular mortality (9% higher risk per 10-unit increase in IMD score; 95% CI 3% to 16%; p=0.003), but not cardiovascular mortality (figure 1). Similarly, IMD score was associated with a higher rate of hospitalisation for non-cardiovascular causes. At first glance, these results seem counter-intuitive. However, this data makes evident the need to treat the entire patient with CHF and not just focus on heart failure treatment alone.
In the accompanying editorial, Squire2 reminds us that “the societal burden associated with CHF is enormous and growing. Similarly, the individual patient burden associated with a diagnosis of CHF is potentially high; this remains a condition associated with significant morbidity and mortality.” He concludes that “It appears clear that patients in areas of high deprivation continue to be at risk of adverse outcomes and that such outcomes may not relate directly to one major diagnosis, such as CHF.”
Despite advances in cardiac surgery over the past several decades, atrial fibrillation (AF) continues to occur commonly in the postoperative period. This is an important problem because postoperative AF is associated with an increased risk of stroke, hospital length of stay and overall mortality. In a study of over 11 000 consecutive patients undergoing coronary artery bypass graft (CABG) between 2002 and 2010, postoperative AF occurred in 29.5% of patients with no previous AF diagnosis, with no change in incidence over this time period (figure 2).3 The adjusted median time from surgery to AF onset was 52 hours with a median total time in AF of 22 hours per patient.
The pathophysiology of AF after CABG surgery has not been fully elucidated and cannot be explained by surgical trauma of atrial tissue given that cardiopulmonary bypass for CABG surgery typically does not include significant manipulation of the left atrium. Thus, as Akoum4 suggests in an editorial, it is likely “that post-CABG AF shares common mechanisms with AF that is not associated with surgery. These include the firing of electrical triggers, a vulnerable atrial substrate composed of both electrical and structural tissue remodelling, all in the presence of a proarrhythmic autonomic milieu.” Many of these patients also have clinical risk factors for AF, so that “The likely cause of this stable incidence is that these risk factors are associated with the development of atrial fibrosis which creates a substrate for AF.” Whether or not we can prevent post-CABG AF by risk factor modification or targeted medical therapy remains an open question; clearly our treatments to date have been ineffective from a population perspective.
Also in this issue of Heart is a state-of-the-art review article on anthracycline cardiotoxicity by Hendricksen5 which discusses mechanism of cardiomyocyte injury, as well as recommendations for monitoring and prevention (figure 3).
The Education in Heart article discusses the causes of sudden death and recommendations for ECG screening for heart disease in athletes.6 You can listen to a short summary and discussion of this article in a podcast with James Rudd interviewing Dr Andrew D’Silva from Brighton, UK, one of the authors of the article. https://soundcloud.com/bmjpodcasts/ecg-screening-for-young-athletes-yes-or-no?in=bmjpodcasts/sets/heart-podcast
The Image Challenge in this issue7 provides a quick review of the causes of left ventricular outflow obstruction and how to differentiate each on echocardiographic imaging.
Competing interests None declared.
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Provenance and peer review Commissioned; internally peer reviewed.