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The association between marital status and outcomes in patients with cardiovascular disease (CVD) has been controversial. In order to address this issue, Wong and colleagues1 performed a meta-analysis that included 34 studies with more than two million participants. Being unmarried, including those who never married, were divorced or widowed, was associated not only with a higher odds of CVD (OR 1.42; 95% CI 1.00 to 2.01) but also with an increased risk of coronary heart disease death (OR 1.43,95% CI 1.28 to 1.60) and stroke death (OR 1.55,95% 1.16 to 2.08) compared to those who were married. (figure 1) The causal mechanism for this association is unknown, although many theories abound.
In an editorial, Raparelli, Proietti, and Basili2 put this data in the context that “While differences in health status and outcomes have been traditionally attributed to biological sex, it is now increasingly recognised …