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Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests Speaker’s and consulting fees from AstraZeneca, Bayer and Sanofi-Aventis.
Patient consent Not required.
Provenance and peer review Commissioned; externally peer reviewed.
Author note References that include an asterisk (*) are considered to be key references.