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74 Left ventricular remodelling post transcatheter aortic valve implantation (TAVI) is dependent on baseline mean gradient and ejection fraction: an echocardiographic study
  1. Sveeta Badiani,
  2. Jet van Zalen,
  3. Anantharaman Ramasamy,
  4. Mick Ozkor,
  5. Anthony Mathur,
  6. Simon Kennon,
  7. Michael Mullen,
  8. Sanjeev Bhattacharyya,
  9. Guy Lloyd
  1. Barts Heart Centre


Background The left ventricular response to aortic stenosis (AS) is complex. Although transcatheter aortic valve implantation (TAVI) decreases the left ventricular afterload by reducing the transvalvular pressure gradient, data regarding its impact on left ventricular geometry is limited. This study sought to assess left ventricular reverse remodelling following transcatheter aortic valve implantation (TAVI).

Methods Data from patients with severe aortic stenosis (AVA <1 cm²) undergoing TAVI at our institution was analysed. Patients without both an in-house pre-and post procedure echocardiogram available for analysis were excluded, as were patients with suboptimal echocardiographic windows. Comprehensive echocardiography was performed prior to and following intervention. Patients were classified into 4 subtypes according to mean gradient and LVEF:

HGNEF High gradient (MG >40 mmHg) and normal ejection fraction (LVEF >55%)

HGREF High gradient (MG >40 mmHg) and reduced ejection fraction (LVEF <55%)

LGNEF Low gradient (MG <40 mmHg) and normal ejection fraction LVEF >55%

LGREF Low gradient (MG <40 mmHg) and reduced ejection fraction (LVEF <55%)

Results 67 patients were included in the final analysis. The mean age was 80.8±7.5 years and 37 patients (55.2%) were female. The median follow up time for echocardiography was 11.1 weeks (IQR 7.6–15.7 weeks). The number of patients were subdivided into: 1. HGNEF 38 (56.7%), 2. HGREF: 13 (19.4%), 3. LGNEF: 4 (6%) and 4. LGREF: 12 (17.9%). Overall, there was a significant reduction in septal thickness and left ventricular mass on the follow up echocardiogram. The decrease in relative wall thickness was not significant:

Interventricular septum (mm) Pre-TAVI 12.3±2.7 vs Post TAVI 11.7±2.6, p=0.027

Posterior wall (mm) 10.8±2.3 vs 10.4±2 p=0.166

LVEDD (mm) 46.3±7.6 vs 45.6±9.4, p=0.867

RWT 0.49±0.15 v‘s 0.46±0.14, p=0.159

LV mass: 199±59 vs 186±51, p=0.016

Patients with high gradient aortic stenosis and preserved left ventricular ejection fraction showed greater decreases in relative wall thickness and left ventricular mass than those with high gradients and reduced ejection fraction and those with low gradient aortic stenosis.

Group 1, HGNEF. Pre TAVI RWT 0.53±0.15 vs Post TAVI RWT 0.47±0.13, Pre TAVI LV mass 188±51 vs 174±48, p=0.028.

Group 2, HGREF. RWT 0.42±0.17 vs 0.44±0.15, LVM 223±70 vs 211±60, p=0.345.

Group 3, LGNEF. RWT 0.47±0.1 vs 0.52±0.23, LVM 178±28 vs 187±60, p=0.854.

Group 4, LGREF RWT 0.42±0.09 vs 0.43±0.13, LVM 215±68 vs 93±39, p=0.308.

Conclusions Our data demonstrates a significant improvement in left ventricular mass following TAVI, which appears to be driven by a reduction in wall thickness. Sub-group analysis suggests that the improvements in left ventricular geometry are more pronounced in patients with high gradient aortic stenosis and preserved ejection fraction.

  • aortic stenosis
  • trans catheter aortic valve implantation
  • echocardiography

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