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16 Prognostic value of high-sensitivity cardiac troponin T in patients with ST-segment-elevation myocardial infarction
  1. N Khullar1,
  2. A Ibrahim2,
  3. J Saunders3,
  4. C Ahern2,
  5. K Mannix2,
  6. C Cahill2,
  7. TJ Kiernan2
  1. 1Graduate Entry Medical School, University of Limerick, Limerick, Ireland
  2. 2Department of Cardiology, University Hospital Limerick, Limerick, Ireland
  3. 3Department of Mathematics and Statistics, University of Limerick, Limerick, Ireland

Abstract

Background The clinical significance of high-sensitivity cardiac troponin T (hs-cTnT) following acute ST-segment-elevation myocardial infarction (STEMI) has not been well established. The aim of this study was to determine the prognostic value of hs-cTnT in the prediction of one-year mortality and repeat revascularisation in STEMI patients.

Methods Single center retrospective observational study of patients presenting with STEMI in 2016. Demographic, angiographic, and peak hs-cTnT data were obtained. The relationship between peak hs-cTnT and all-cause mortality and repeat revascularisation was examined.

Results 208 patients were included. Mean age was 63.56 years (±12.56), and 73% were males. 78 (37.5%) patients had inferior STEMI and 76 (36.5%) patients had anterior STEMI. 193 (92.8%) patients received primary percutaneous coronary intervention. Median peak hs-cTnT was 2908 ng/L (IQR: 1095, 5485) (<14 ng/L), measured at a median of 1 day from admission; median creatinine of 75 μmol/L (IQR: 68, 95). 18 (8.7%) patients died, and 35 (16.8%) had repeat revascularisation within one year. No significant relationship between peak hs-cTnT and one-year mortality (p=0.150) (figure 1) or repeat revascularisation (p=0.204) (figure 2) was found.

Abstract 16 Figure 1
Abstract 16 Figure 1

1 year mortality

Abstract 16 Figure 2
Abstract 16 Figure 2

1 year revascularisation

Conclusion Peak hs-cTnT measurements did not predict all-cause mortality or repeat revascularisation. The significance of performing routine peak hs-cTnT measurements in STEMI patients should be investigated further in larger studies.

http://dx.doi.org/10.1136/heartjnl-2018-ICS.16

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