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Original research article
Right ventricular fibrosis is associated with cardiac remodelling after pulmonary valve replacement
  1. Kenichiro Yamamura1,
  2. Darren Yuen2,3,
  3. Edward J Hickey1,4,
  4. Xiaolin He2,3,
  5. Rajiv R Chaturvedi5,
  6. Mark K Friedberg5,
  7. Lars Grosse-Wortmann5,6,
  8. Kate Hanneman7,
  9. Filio Billia1,
  10. Michael E Farkouh1,
  11. Rachel M Wald1,3,5,7
  1. 1 Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada
  2. 2 Division of Nephrology, Department of Medicine, St. Michael’s Hospital and University of Toronto, Toronto, Ontario, Canada
  3. 3 Keenan Research Centre for Biomedical Science, St. Michael’s Hospital, Toronto, Ontario, Canada
  4. 4 Division of Cardiovascular Surgery, Department of Surgery, University of Toronto, SickKids Hospital, Toronto, Ontario, Canada
  5. 5 Division of Cardiology, Department of Pediatrics, The Labatt Family Heart Center, University of Toronto, SickKids Hospital, Toronto, Ontario, Canada
  6. 6 Department of Diagnostic Imaging, University of Toronto, SickKids Hospital, Toronto, Ontario, Canada
  7. 7 Department of Medical Imaging, University of Toronto, Peter Munk Cardiac Centre, Toronto General Hospital, Toronto, Ontario, Canada
  1. Correspondence to Dr Rachel M Wald, Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, Toronto General Hospital, Toronto, ON M5G 2N2, Canada; Rachel.Wald{at}uhn.ca

Footnotes

  • Contributors KY and RMW conceived and designed the research, acquired data, performed statistical analysis, drafted the manuscript and critically reviewed the manuscript. DY, EJH, XH and KH acquired data, wrote the first draft and critically reviewed the manuscript. RRC, MKF, LG-W, FB and MEF wrote the first draft and critically reviewed the manuscript. All authors interpreted the results and approved the final version of the manuscript.

  • Funding Canadian Institutes of Health Research Operating Grant (MOP 119353) to RW.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval The study protocol was approved by the institutional research ethics board (study number 12–0242).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • Contributors KY and RMW conceived and designed the research, acquired data, performed statistical analysis, drafted the manuscript and critically reviewed the manuscript. DY, EJH, XH and KH acquired data, wrote the first draft and critically reviewed the manuscript. RRC, MKF, LG-W, FB and MEF wrote the first draft and critically reviewed the manuscript. All authors interpreted the results and approved the final version of the manuscript.

  • Funding Canadian Institutes of Health Research Operating Grant (MOP 119353) to RW.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval The study protocol was approved by the institutional research ethics board (study number 12–0242).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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