Footnotes

• Contributors All listed authors provide substantial contributions to the conception or design of the work, or the acquisition, analysis or interpretation of data, drafting the work or revising it critically for important intellectual content, provided final approval of the version published and an agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

• Funding ZS acknowledges funding support from the Experimental Medicine Training Initiative (RG81329), University of Cambridge. JC and ZS acknowledge funding support from the NIHR Cambridge Biomedical Research Centre, Cambridge University Hospitals NHS Foundation Trust.

• Competing interests None declared.

• Provenance and peer review Commissioned; externally peer reviewed.

• Patient consent for publication Not required.