Article Text

Download PDFPDF
Original research article
Cardiac magnetic resonance in patients with elevated troponin and normal coronary angiography
  1. Subir Bhatia1,
  2. Christopher Anstine1,
  3. Allan S Jaffe2,
  4. Bernard J Gersh2,
  5. Krishnaswamy Chandrasekaran2,
  6. Thomas A Foley2,3,
  7. David Hodge4,
  8. Nandan S Anavekar2,3
  1. 1 Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
  2. 2 Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA
  3. 3 Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA
  4. 4 Department of Health Sciences Research, Mayo Clinic, Jacksonville, Florida, USA
  1. Correspondence to Dr Nandan S Anavekar; anavekar.nandan{at}


Background Invasive angiography in the setting of cardiac troponin elevation may reveal non-obstructive coronary arteries leading to uncertainty in diagnosis. Cardiac MR (CMR) may aid in diagnosis, however, the spectrum of diagnostic findings in the patient presenting with symptoms of cardiac ischaemia, elevated cardiac biomarkers and a negative invasive coronary angiogram is yet to be completely described.

Methods We queried the Mayo Clinic, Rochester inpatient record from 1 January 2000 to 31 December 2016 to identify patients who: (1) had an elevated troponin T during admission, (2) underwent coronary angiography within 30 days of troponin T elevation which was considered negative for obstructive coronary arterial disease and (3) underwent CMR within 30 days of troponin T elevation. CMR diagnoses were classified as either (1) myocarditis, (2) small area myocardial infarction, (3) stress cardiomyopathy, (4) non-ischaemic cardiomyopathy or (5) normal.

Results Of 215 patients, the spectrum of disease seen on CMR was myocarditis (32%), small area infarction (22%), non-ischaemic cardiomyopathy (20%) and stress cardiomyopathy (9.3%).

Conclusion In the largest single-centre study assessing the role of CMR in patients admitted with elevated troponin T with a non-obstructive coronary disease on an angiogram, small area infarction was seen in 22% of patients.

  • cardiac magnetic resonance (cmr) imaging
  • acute myocardial infarction

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Contributors SB and CA: involved in data collection, study design and manuscript preparation. AJ, BG, KC and TF: involved in manuscript review. DH: involved in statistical support. NA: involved in study design and manuscript review.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Ethics approval The study received approval from the Mayo Clinic Institutional Review Board (IRB).

  • Provenance and peer review Not commissioned; externally peer reviewed.

Linked Articles

  • Editorial
    Udo Sechtem Andreas Seitz Peter Ong