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To the Editor,
The study by Akyea et al 1 raises a number of issues. First, the authors have not presented any all-cause mortality data. This is of vital importance when evaluating a preventative measure; not only is preventing death from particular causes relevant but overall mortality must be reduced for effectiveness to be claimed.
The ‘lack of response’ in over half of the patients demonstrates the problem seen with oversimplification of physiology. Low-density lipoprotein (strictly speaking not LDL-cholesterol) …
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; internally peer reviewed.
Patient consent for publication Not required.