Statistics from Altmetric.com
- premature ventricular beats
- ventricular arrhythmia ablation procedures
- heart failure with reduced ejection fraction
The first publications about the relevance of premature ventricular complexes (PVCs) appeared in the late 1970s.1 In patients with frequent PVCs without structural heart disease, the prognosis was no worse than in the general population. Therefore, it has been generally accepted that prognosis is linked to the presence or absence of structural heart disease rather than with the presence of PVC itself. On the other hand, ablation may improve ventricular ejection fraction in patients with frequent PVCs and systolic dysfunction.2 Those initial descriptions of the so-called PVC-induced cardiomyopathy increased the interest in the prognosis of patients with frequent PVCs.
Cohort studies have shown a relation between PVC burden, deterioration of left ventricular ejection fraction (LVEF)3 4 and cardiovascular events.4 5 Patients with the highest PVC burden (first quartile) showed three times greater odds of 5-year decrease in LVEF and an increased risk of heart failure and death.4 Therefore, it seems that frequent PVCs may result in left ventricular deterioration even in the absence of structural heart disease. Ablation of PVCs may improve LVEF in patients with left ventricular dilation or systolic dysfunction, …
Contributors Both authors have contributed to the editorial comment by reviewing the literature, writing the comment and reviewing the paper.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.
Patient consent for publication Not required.
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.