Footnotes

• Contributors All authors contributed to the review of the primary paper and literature review and were part of the Original Ochsner studies discussed; this is a Review/Editorial, but all authors reviewed and edited the manuscript and approved the final paper.

• Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

• Competing interests None declared.

• Patient consent Not required.

• Provenance and peer review Not commissioned; externally peer reviewed.