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Asymptomatic severe aortic stenosis: biomarkers are welcome
  1. Manuel Martinez-Selles1,
  2. Antoni Bayes-Genis2
  1. 1 Servicio de Cardiología, Hospital Universitario Gregorio Marañón, CIBERCV. Universidad Europea. Universidad Complutense, Madrid, Spain
  2. 2 Institut del Cor, Hospital Universitari Germans Trias i Pujol, CIBERCV, UAB, Badalona, Spain
  1. Correspondence to Dr Manuel Martinez-Selles, Servicio de Cardiología, Hospital Universitario, Madrid 28007, Spain; mmselles{at}

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Calcified aortic stenosis (AS) is the most common form of valvular heart disease in the developed world. Severe AS has >7% prevalence among those older than 80 years.1 Current guidelines recommend aortic valve intervention with a class I indication for patients with symptomatic severe AS. Indications have been expanded for asymptomatic patients with severe AS to include those with a left ventricular ejection fraction (LVEF) of <50%, a positive exercise stress test, decreased blood pressure on stress testing or critical AS (specifically peak aortic jet velocity (Vmax) ≥5 m/s). However, the management of patients with asymptomatic severe AS who are not covered by these recommendations still represents a clinical conundrum. A close surveillance (‘watchful waiting’) strategy is usually adopted in this situation, and decisions are made on an individual basis. Some patients with asymptomatic severe AS and normal LVEF are inevitably more vulnerable to future adverse events than others; therefore, the identification of potential biomarkers that might be helpful in the risk stratification of these patients is of particular importance.

In their Heart paper, Nakatsuma et al 2 present a commendable study including a large multicentre cohort of 387 patients with asymptomatic severe AS and a mean age of 80 years from the Contemporary outcomes after sURgery and medical …

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  • Contributors MMS drafted the editorial and ABG made an important contribution.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Not required.

  • Provenance and peer review Commissioned; internally peer reviewed.

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