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Patient-specific computer simulation for transcatheter cardiac interventions: what a clinician needs to know
  1. Peter de Jaegere1,
  2. Giorgia Rocatello2,
  3. Bernard D Prendergast3,
  4. Ole de Backer4,
  5. Nicolas M Van Mieghem1,
  6. Ronak Rajani3
  1. 1 Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands
  2. 2 IBiTech-bioMMeda, Ghent University, Ghent, Belgium
  3. 3 Department of Cardiology, Guy’s and St Thomas’ NHS Foundation Trust London, London, UK
  4. 4 Department of Cardiology, Rigshospitalet University Hospital, Copenhagen, Denmark
  1. Correspondence to Dr Peter de Jaegere, Department of Cardiology, Erasmus University, Rotterdam 3015CE, The Netherlands; p.dejaegere{at}


Patient-specific computer simulation consists of the assessment of the interaction of the device with the host based on the integration of the detailed geometric and biomechanical properties of the device and host. Hence, it allows the prediction of valve performance (efficacy) and complications (safety) and may consequently help the physician to select the valve/device that best fits the individual patient, thereby improving outcome. There is currently little awareness and information in clinical medicine on patient-specific computer simulation. In this paper, we describe the technical background and a number of illustrations to illustrate how patient-specific computer simulation may be used for catheter-based treatment planning of acquired heart disease.

  • transcatheter valve interventions
  • aortic stenosis
  • mitral regurgitation

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  • Contributors All coauthors critically reviewed the content of the paper.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests GR is an engineer and employee of Feops, Ghent, Belgium.

  • Provenance and peer review Commissioned; externally peer reviewed.

  • Patient consent for publication Not required.