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128 The impact of aortic valve replacement on survival in patients with normal flow low gradient severe aortic stenosis: a propensity-matched comparison
  1. Roxy Senior1,
  2. Sahrai Saeed2,
  3. Anastasia Vamvakidou3,
  4. Rajdeep Khattar4,
  5. Wei Li4
  1. 1Royal Brompton Hospital and National Heart and Lung Institute, Imperial College, London
  2. 2Haukeland University Hospital, Bergen, NO
  3. 3Northwick Park Hospital
  4. 4Royal Brompton Hospital


Introduction To assess the survival benefit of aortic valve replacement (AVR) in patients with normal flow low gradient severe aortic stenosis (AS).

Methods A retrospective study of prospectively collected data of 276 patients (mean age 75±15 years, 51% male) with normal transaortic flow (flow rate [FR] ≥200 ml/s or stroke volume index [SVi] ≥35 ml/m2) and severe AS (aortic valve area [AVA] <1.0 cm2. The outcome measure was all-cause mortality.

Results Of the 276 patients, 55% (n=151) were medically treated while 45% (n=125) underwent an AVR. Over a mean follow-up of 3.2±1.8 years (range 0–6.9 years) a total of 96 (34.8%) deaths occurred: 17 (13.6%) in AVR group versus 79 (52.3%) in those medically treated, when transaortic flow was defined by FR (p<0.001) (figure 1). When transaortic flow was defined by SVi, a total of 79 (31.3%) deaths occurred: 18 (15.1%) in AVR group versus 61 (45.9%) in medically treated (p<0.001). In a propensity-matched multivariable Cox regression analysis adjusting for age, gender, body surface area, smoking, hypertension, diabetes mellitus, atrial fibrillation, peripheral vascular disease, chronic kidney disease, left ventricular ejection fraction, left ventricular mass and mean aortic gradient, not having AVR was associated with a 6.3 fold higher HR of all-cause mortality (HR 6.28; 95% CI 3.34–13.16, p<0.001) when flow was defined by FR. In the SVi-guided model it was 3.83 fold (HR 3.83; 95% CI 2.30–6.37, p<0.001).

Conclusion In patients with normal flow low gradient severe AS, AVR was associated with a significantly improved survival compared to those who received standard medical treatment.

Conflict of Interest No

  • Aortic stenosis
  • Normal flow low gradient
  • Outcomes

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