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156 The derivation of troponin-only manchester acute coronary syndromes (T-MACS) decision aid with alere point of care for ruling out acs in patients with chest pain presented to emergency department
  1. Abdulrhman Alghamdi1,
  2. Charles Reynard2,
  3. Richard Body1
  1. 1The university of Manchester
  2. 2Manchester University NHS Foundation Trust


Introduction The Troponin-only Manchester Acute Coronary Syndromes (T-MACS) decision aid is a prospectively validated tool to rule-in and rule-out acute coronary syndromes (ACS) using a single blood test in the Emergency Department (ED). T-MACS has been validated with laboratory-based cardiac troponin (cTn) assays. The rapid turnaround time of point of care (POC) cTn assays has great potential advantages for busy EDs. We therefore aimed to evaluate the diagnostic accuracy of T-MACS using a contemporary POC cTn assay.

Method We conducted a secondary analysis of the Bedside Evaluation of Sensitive Troponin (BEST) study, a prospective diagnostic accuracy study at 14 UK centres. We included adults with chest pain of <12 hours duration, which the treating physician suspected to be ACS. We excluded patients with ST elevation myocardial infarction; patients with another medical condition requiring hospitalization; and patients lacking capacity to provide written informed consent. Blood was drawn on arrival and 3 hours later for POC cTnI using the Alere Cardiac Triage 3 assay (99th percentile 0.02ng/ml). The accuracy of T-MACS was calculated using (a) the result on arrival alone (T0 analysis); and (b) the maximum POC cTn result based on presentation and 3-hour samples (T3 analysis).

The target condition was acute myocardial infarction (AMI), which was adjudicated by two investigators based on serial cTn testing over 3–6 hours. We also followed patients for major adverse cardiac events (MACE; including death, AMI or coronary revascularization) at 30 days.

Results After excluding patients with incomplete data or follow-up (n= 432), we included 373 patients with full data for T-MACS at T0; and 330 who had available samples drawn at 3h. In total 61 (15.8%) patients had AMI and 72 (18.7%) had one or more MACE at 30 days.

Using POC Alere cTnI with T-MACS rule had an area under the receiver operating characteristic curve of 0.915 at T0 and 0.921 at T3. Also, this study has shown that with the Alere POC cTn assay, T-MACS at T0 could have immediately ruled-out AMI in 131 (35.1%) patients. Of those patients, 3 would have had missed AMI (2.3%) and 2 (1.5%) had another MACE within 30 days. With a repeat test at 3h, T-MACS could have ruled-out 110 (33.3%) patients, missing just one AMI (0.9%) and 2 (1.8%) had another MACE within 30 days. In addition, T-MACS could rule-in AMI in 43 (11.5%) patents at T0, of which 36 (83.7%) had AMI; and in 48 (14.5%) patients at T3, of which 40 (83.3%) had AMI (figure 1).

Conclusion In conclusion, using T-MACS with the Alere Cardiac Triage 3 POC cTnI assay has insufficient sensitivity to rule-out ACS with one test. It could, however, potentially be used to rule-out ACS when central laboratory assays are unavailable and could be used to enable early rule-in of ACS in the ED.

Conflict of Interest Alere (donation of reagents)

  • Acute coronary syndromes
  • Cardiac troponin
  • Clinical decision rule

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