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Cold feet, warm heart

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  • Contributors RB prepared the first draft. RB, MH and DEN reviewed and edited the final manuscript. All authors are responsible for the overall content.

  • Funding This work was supported by the British Heart Foundation (CH/09/002, RE/13/3/30183, RE/18/5/34216, PG/19/40/34422 and RG/16/10/32375 to DEN) and the Wellcome Trust (WT103782AIA to DEN).

  • Competing interests None declared.

  • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.