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Contributors RB prepared the first draft. RB, MH and DEN reviewed and edited the final manuscript. All authors are responsible for the overall content.
Funding This work was supported by the British Heart Foundation (CH/09/002, RE/13/3/30183, RE/18/5/34216, PG/19/40/34422 and RG/16/10/32375 to DEN) and the Wellcome Trust (WT103782AIA to DEN).
Competing interests None declared.
Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.
Patient consent for publication Obtained.
Provenance and peer review Not commissioned; externally peer reviewed.